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Role of the miRNA Pathway in Aging


Elder CR, Pasquinelli AE. New roles for microRNAs in old worms. Front Aging. 2022 Apr 12;3:871226. doi: 10.3389/fragi.2022.871226. eCollection 2022.PMID: 35821862. PMCID: PMC9261348

Primary Research
Chipman LB, Luc S, Nicastro IA, Hulahan JJ, Dann DC, Bodas DM, Pasquinelli AE. Expression, not sequence, distinguishes miR-238 from its miR-239ab sister miRNAs in promoting longevity in Caenorhabditis elegans. PLoS Genet. 2023 Nov 27;19(11):e1011055. doi: 10.1371/journal.pgen.1011055. eCollection 2023 Nov. PMCID:PMC10703411

Aalto AP, Nicastro IA, Broughton JP, Chipman LB, Schreiner WP, Chen JS, Pasquinelli AE. Opposing roles of microRNA Argonautes during Caenorhabditis elegans aging. PLoS Genet. 2018 Jun 21;14(6):e1007379. doi: 10.1371/journal.pgen.1007379. eCollection 2018 Jun. PMCID: PMC6013023

Studying the role of the miRNA pathway in aging C. elegans